This room displays a selection of medieval and modern works from the city of Este and the surrounding area. This is a significant, albeit contained, nucleus documenting the continuity of local artistic production between the 8th and 16th centuries, with extensions to the 19th century in the ceramics section. The paintings, sculptures and architectural elements come from churches and buildings that in some cases have disappeared or been transformed. These artifacts came to the museum thanks to the preservation activities carried out mainly by early directors, such as Alessandro Prosdocimi and Adolfo Callegari, who helped save them from dispersion.
The exhibits include an 8th-century ambo lounger from Megliadino San Fidenzio and a fresco of Giottesque scope from Galzignano, as well as works from the churches of Este, such as the 16th-century pair of saints from San Martino, the wooden Pietà and the precious Madonna and Child by Cima da Conegliano (1504) from Santa Maria delle Consolazioni.
Museum route